〒567-0085
大阪府茨木市彩都あさぎ7-6-8
TEL:072-641-9012(内線2402)
MAIL:moka@nibiohn.go.jp

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研究業績

原著論文および英語総説

Oka M., Otani M., Miyamoto Y., Oshima R., Adachi J., Tomonaga T., Asally M., Nagaoka Y., Tanaka K., Toyoda A., Ichikawa K., Morishita S., Isono K., Koseki H., Nakato R., Ohkawa Y., Yoneda Y. Phase-separated nuclear bodies of nucleoporin fusions promote condensation of MLL1/CRM1 and rearrangement of 3D genome structure. Cell Rep. 42(8):112884 (2023)

Katahira J., Ohmae T., Yasugi M., Sasaki R., Itoh Y., Kohda T., Hieda H., Yokota-Hirai M., Okamoto T., Miyamoto Y. Nsp14 of SARS-CoV-2 inhibits mRNA processing and nuclear export by targeting the nuclear cap-binding complex. Nucleic Acids Res., Jun 1;gkad483 (2023)

Khandakar GI., Miyamoto Y.,  Kishimoto K., Xie M., Shih M., Satoh R., Takasaki T., Tanabe G., Oka M., Sugiura R. ACAGT-007a, an anti-cancer compound that modulates ERK MAPK signaling, induces nuclear enrichment of phosphorylated ERK in T3M4 pancreatic cancer cells. Genes Cells, 28(6):457-465 (2023)

Wang W., Miyamoto Y. (co-first), Chen B., Shi J., Diao F., Zheng W., Li Q., Yu L., Li L., Xu Y., Wu L., Mao X., Fu J., Li B., Yan Z., Shi R., Xue X., Mu J., Zhang Z., Wu T., Zhao L., Wang W., Zhou Z., Dong J., Li Q., Jin L., He L., Sun X., Lin G., Kuang Y., Wang L., Sang Q. Karyopherin α deficiency contributes to human preimplantation embryo arrest. J. Clin., Invest. 133(2):e159951 (2023)

Aomine Y., Sakurai K., Macpherson T., Ozawa T., Miyamoto Y., Yoneda Y., Oka M., Hikida T. Importin α3 (KPNA3) deficiency augments effortful reward-seeking behavior in mice. Frontiers in Neuroscience,16:905991 (2022)

Yamada K., Motohashi S., Oikawa T., Tago N., Koizumi R., Ono M., Tachibana T., Yoshida A., Yoshida S., Shimoda M., Oka M., Yoneda Y., Yoshida K. Extended-synaptotagmin 1 engages in unconventional protein secretion mediated via SEC22B+ vesicle pathway in liver cancer. Proc. Natl. Acad. Sci. U S A, 119(36):e2202730119 (2022)

Miyamoto Y., Itoh Y., Suzuki T., Tanaka T., Sakai Y., Koido M., Hata C., Wang CX., Otani M., Moriishi K., Tachibana T., Kamatani Y., Yoneda Y., Okamoto T., Oka M. SARS-CoV-2 ORF6 disrupts nucleocytoplasmic trafficking to advance viral replication. Commun. Biol. 5(1):483 (2022)

Sakurai K., Ito T., Morita M., Kasahara E., Moriyama T., Macpherson T., Ozawa T., Miyamoto Y., Yoneda T., Sekiyama A., Oka M., Hikida T. Effects of Importin α1/KPNA1 deletion and adolescent social isolation stress on psychiatric disorder-associated behaviors in mice. PLOS One, 16(11), e0258364 (2021)

Nathaniel B., Whiley P.A.F., Miyamoto Y., Loveland K.L. Importins: Diverse roles in male fertility. Semin. Cell Dev. Biol., S1084-9521(21), 00206-8 (2021)

Miyamoto Y., Sasaki M., Miyata H., Monobe Y., Nagai M., Otani M., Whiley P.A.F., Morohoshi A., Oki S., Matsuda J., Akagi K., Adachi J., Okabe M., Ikawa M., Yoneda Y., Loveland K.L. Oka M. Genetic loss of importin α4 causes abnormal sperm morphology and impacts on male fertility in mouse. FASEB J., 34,16224–16242 (2020)

Tokunaga M., Miyamoto Y.(co-first), Suzuki T., Otani M., Inuki S., Esaki T., Nagao C., Mizuguchi K., Ohno H., Yoneda Y., Okamoto T., Oka M., Matsuura Y. Novel anti-flavivirus drugs targeting the nucleolar distribution of core protein. Virology, 541, 41-51 (2020)

Oka M., Mura S., Otani M., Miyamoto Y., Nogami J., Maehara K., Harada A., Tachibana T., Yoneda Y., Ohkawa Y. Chromatin-bound CRM1 recruits SET-Nup214 and NPM1c onto HOX clusters causing aberrant HOX expression in leukemia cells. Elife, 8. pii: e46667 (2019)

Oka M. and Yoneda Y. Importin α: functions as a nuclear transport factor and beyond, Proceedings of the Japan Academy, Series B, 94: 259-274 (2018)

Miyamoto Y., Whiley P.A.F, Goh H., Wong C., Higgins G., Tachibana T., McMenamin P., Mayne L., Loveland K.L The Stk35 locus contributes to normal gametogenesis and encodes a lncRNA responsive to oxidative stress. Biol Open, 7: bio032631 (2018)

Tanaka T., Kasahara Y., Miyamoto Y., Takumi O., Kasai T., Onodera K., Kuwahara M., Oka M., Yoneda Y., Obika S. Development of oligonucleotide-based antagonists of Ebola virus protein 24 inhibiting its interaction with karyopherin α1. Org. Biomol. Chem., 16: 4456-4463 (2018)

Higa M., Oka M., Fujihara Y., Masuda K., Yoneda Y. Kishimoto T. Regulation of inflammatory responses by dynamic subcellular localization of RNA-binding protein Arid5a. PNAS, 115: E1214-E1220 (2018)

Miyamoto Y., Yoneda Y., Oka M. Protein Transport Between the Nucleus and Cytoplasm, Nuclear Architecture and Dynamics, Academic press, Chapter 17: 387-403 (2018)

Moriyama T., Tanaka S., Nakayama Y., Fukumoto M., Tsujimura K., Yamada K., Bamba T., Yoneda Y., Fukusaki E., Oka M. Two isoforms of TALDO1 generated by alternative translational initiation show differential nucleocytoplasmic distribution to regulate the global metabolic network. Sci. Rep., 6: 34648 (2016)

Miyamoto Y., Yamada K., Yoneda Y. Importin α: a key molecule in nuclear transport and non-transport functions. J. Biochem., 160: 69-75 (2016)

Miyamoto Y., Oka M. Data on dimer formation between importin α subtypes. Data Brief, 7: 1248-1253 (2016)

Yamada K., Miyamoto Y., Tsujii A., Moriyama Y., Ikuno Y., Shiromizu T., Serada S., Fujimoto M., Tomonaga T., Naka T., Yoneda Y. Oka M. Cell surface localization of importin α1/KPNA2 affects cancer cell proliferation by regulating FGF1 signalling. Sci. Rep., 6: 231410 (2016)

Oka M., Mura S., Yamada K., Sangel P., Hirata S., Maehara K., Kawakami K., Tachibana T., Ohkawa Y., Kimura H., Yoneda Y. Chromatin-prebound Crm1 recruits Nup98-HoxA9 fusion to induce aberrant expression of Hox cluster genes. eLIFE, 5: e09540 (2016)

Tsujii A., Miyamoto Y., Moriyama T., Tsuchiya T., Obuse C., Mizuguchi K., Oka M., Yoneda Y. Retinoblastoma Binding Protein 4-Regulated Classical Nuclear Transport Is Involved in Cellular Senescence. J. Biol. Chem., 290: 29375–29388 (2015)

Kimoto C., Moriyama T., Tsujii A., Igarashi Y., Obuse C., Miyamoto Y., Oka M. and Yoneda Y. Functional characterization of importin α8 as a classical nuclear localization signal receptor. Biochim. Biophys. Acta - Molecular Cell Research, 1853: 2676-2683 (2015)

Moriyama T., Percival A. P., Yamaguchi D., Obuse C., Miyamoto Y., Oka M., Yoneda Y. Identification and characterization of a nuclear localization signal of TRIM28 that overlaps with the HP1 Box. Biochem. Biophys. Res. Commun., 462: 201–207 (2015)

Sangel P., Oka M. and Yoneda Y. The role of importin-βs in the maintenance and lineage commitment of mouse embryonic stem cells. FEBS Open Bio, 4: 112-120 (2014)

Oka M., Moriyama T., Asally M., Kawakami K. and Yoneda Y. Differential role for transcription factor Oct4 nucleocytoplasmic dynamics in somatic cell reprogramming and self-renewal of embryonic stem cells. J. Biol. Chem., 288: 15085-15097 (2013)

Yasuhara N., Yamagishi R., Arai Y., Mehmood R., Kimoto C., Fujita T., Touma K., Kaneko K., Kamikawa Y., Moriyama Y., Yanagida T., Kaneko H. and Yoneda Y. Importin alpha subtypes determine differential transcription factor localization in embryonic stem cells maintenance. Dev. Cell, 26: 123-135 (2013)

Mizuguchi-Hata C., Ogawa Y., Oka M. and Yoneda Y. Quantitative regulation of nuclear pore complex components by O-GlcNAcylation. Biochim. Biophys. Acta -Molecular Cell Research, 1833: 2682-2689 (2013)

Tanaka S., Nakano K., Sekimoto T., Oka M. and Yoneda Y. Cell density-dependent nuclear accumulation of ELK3 is involved in suppression of PAI-1 expression.Cell Struct. Funct. 38: 145-154 (2013)

Oka M., Moriyama T., Asally M., Kawakami K. and Yoneda Y. Differential role for transcription factor Oct4 nucleocytoplasmic dynamics in somatic cell reprogramming and self-renewal of embryonic stem cells. J. Biol. Chem., 288: 15085-15097 (2013)

Nagai M. and Yoneda Y. Downregulation of the small GTPase Ras-related nuclear protein accelerates cellular ageing. Biochim. Biophys. Acta -General Subjects, 1830: 2813-2819 (2012)

Miyamoto Y., Loveland K.L. and Yoneda Y. Nuclear importin α and its physiological importance. Commun. Integr. Biol., 5: 220-222 (2012)

Ogawa Y., Miyamoto Y., Oka M. and Yoneda Y. The interaction between importin-α and Nup153 promotes importin-α/β-mediated nuclear import. Traffic, 13: 934-946 (2012)

Yasuda Y., Miyamoto Y.(co-first), Yamashiro T., Asally M., Masui A., Loveland K.L. and Yoneda Y. Nuclear retention of importin α coordinates cell fate through changes in gene expression. EMBO J., 31: 83-94 (2012)

Sekimoto T. and Yoneda Y. Intrinsic and extrinsic negative regulators of nuclear protein transport processes. Genes Cells, 17: 525-35 (2012)

日本語総説

宮本洋一、米田悦啓「核-細胞質間蛋白質輸送と創薬研究」医学のあゆみ 267 No.13, p966-970 (2018)

盛山哲嗣、岡 正啓「核ー細胞質間輸送」生体の科学 第66卷 第5号、p488-489 (2015)

宮本洋一、盛山哲嗣「インポーティンαファミリーと高次生命機能」生化学 第87巻 第1号、p16-21 (2015)

辻井聡、 岡正啓「老化と核-細胞質間輸送制御」生化学 第87巻 第1号、 p22-26 (2015)

宮本洋一「創薬ターゲットとしての核-細胞質間物質輸送」バイオサイエンス&インダストリー 第73卷 第4号、p288-291 (2015)

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