Khandakar GI., Miyamoto Y., Kishimoto K., Xie M., Shih M., Satoh R., Takasaki T., Tanabe G., Oka M., Sugiura R. ACAGT-007a, an anti-cancer compound that modulates ERK MAPK signaling, induces nuclear enrichment of phosphorylated ERK in T3M4 pancreatic cancer cells. Genes Cells, 1-9 (2023)
カテゴリー: 原著論文および英語総説
核輸送分子KPNA7（Importin α8）の遺伝的変異が女性不妊症に関係することを示した共著論文がThe Journal of Clinical Investigationに採択されました。
Wang W., Miyamoto Y. (co-first), Chen B., Shi J., Diao F., Zheng W., Li Q., Yu L., Li L., Xu Y., Wu L., Mao X., Fu J., Li B., Yan Z., Shi R., Xue X., Mu J., Zhang Z., Wu T., Zhao L., Wang W., Zhou Z., Dong J., Li Q., Jin L., He L., Sun X., Lin G., Kuang Y., Wang L., Sang Q. Karyopherin α deficiency contributes to human preimplantation embryo arrest. J. Clin., Invest. 133(2):e159951 (2023)
核輸送分子Kpna3（Importin α3）が精神疾患に関連する動機づけ制御に関係することを発見した共著論文がFrontiers in Neuroscienceに掲載されました。
Aomine Y., Sakurai K., Macpherson T., Ozawa T., Miyamoto Y., Yoneda Y., Oka M., Hikida T. Importin α3 (KPNA3) deficiency augments effortful reward-seeking behavior in mice. Frontiers in Neuroscience,16:905991 (2022)
Yamada K., Motohashi S., Oikawa T., Tago N., Koizumi R., Ono M., Tachibana T., Yoshida A., Yoshida S., Shimoda M., Oka M., Yoneda Y., Yoshida K. Extended-synaptotagmin 1 engages in unconventional protein secretion mediated via SEC22B+ vesicle pathway in liver cancer. Proc. Natl. Acad. Sci. U S A, 119(36):e2202730119 (2022)
SARS-CoV-2 ORF6による核輸送抑制機構に関する論文がCommunications Biologyに掲載されました。
Miyamoto Y., Itoh Y., Suzuki T., Tanaka T., Sakai Y., Koido M., Hata C., Wang CX., Otani M., Moriishi K., Tachibana T., Kamatani Y., Yoneda Y., Okamoto T., Oka M. SARS-CoV-2 ORF6 disrupts nucleocytoplasmic trafficking to advance viral replication. Commun. Biol. 5(1):483 (2022)
KPNA1論文
Sakurai K., Ito T., Morita M., Kasahara E., Moriyama T., Macpherson T., Ozawa T., Miyamoto Y., Yoneda T., Sekiyama A., Oka M., Hikida T. Effects of Importin α1/KPNA1 deletion and adolescent social isolation stress on psychiatric disorder-associated behaviors in mice. PLOS One, 16(11), e0258364 (2021)
共著総説がSeminars in Cell and Developmental Biologyに掲載されました。
Nathaniel B., Whiley P.A.F., Miyamoto Y., Loveland K.L. Importins: Diverse roles in male fertility. Semin. Cell Dev. Biol., S1084-9521(21), 00206-8 (2021)
核輸送分子Importin α4がマウス精子の正常な形態形成と機能に重要であることを示した論文がFASEB J.に掲載されました。
Miyamoto Y., Sasaki M., Miyata H., Monobe Y., Nagai M., Otani M., Whiley P.A.F., Morohoshi A., Oki S., Matsuda J., Akagi K., Adachi J., Okabe M., Ikawa M., Yoneda Y., Loveland K.L. Oka M. Genetic loss of importin α4 causes abnormal sperm morphology and impacts on male fertility in mouse. FASEB J., 34,16224–16242 (2020)
核小体を標的とした抗フラビウイルス増殖抑制薬剤のスクリーニング系開発に関する論文がVirologyに掲載されました。
Tokunaga M., Miyamoto Y.(co-first), Suzuki T., Otani M., Inuki S., Esaki T., Nagao C., Mizuguchi K., Ohno H., Yoneda Y., Okamoto T., Oka M., Matsuura Y. Novel anti-flavivirus drugs targeting the nucleolar distribution of core protein. Virology, 541, 41-51 (2020)
白血病細胞における核外輸送因子CRM1の新機能発見の論文がeLifeに掲載されました。
Oka M., Mura S., Otani M., Miyamoto Y., Nogami J., Maehara K., Harada A., Tachibana T., Yoneda Y., Ohkawa Y. Chromatin-bound CRM1 recruits SET-Nup214 and NPM1c onto HOX clusters causing aberrant HOX expression in leukemia cells. Elife, 8. pii: e46667 (2019)
核輸送に関する新しい総説がProceedings of the Japan Academy, Series Bに掲載されました。
Oka M. and Yoneda Y. Importin α: functions as a nuclear transport factor and beyond, Proceedings of the Japan Academy, Series B, 94: 259-274 (2018)
Stk35 遺伝子ノックアウトマウスと長鎖非翻訳RNAの発現を解析した論文がBiology Openに掲載されました。
Miyamoto Y., Whiley P.A.F, Goh H., Wong C., Higgins G., Tachibana T., McMenamin P., Mayne L., Loveland K.L The Stk35 locus contributes to normal gametogenesis and encodes a lncRNA responsive to oxidative stress. Biol Open, 7: bio032631 (2018)
エボラウイルスVP24と核輸送分子karyopherin alpha1との相互作用を阻害する人工核酸アプタマーに関する論文がOrganic & Biomolecular Chemistryに掲載されました。
Tanaka T., Kasahara Y., Miyamoto Y., Takumi O., Kasai T., Onodera K., Kuwahara M., Oka M., Yoneda Y., Obika S. Development of oligonucleotide-based antagonists of Ebola virus protein 24 inhibiting its interaction with karyopherin α1. Org. Biomol. Chem., 16: 4456-4463 (2018)
核タンパク質輸送と炎症に関する論文がPNASに掲載されました。
Higa M., Oka M., Fujihara Y., Masuda K., Yoneda Y. Kishimoto T. Regulation of inflammatory responses by dynamic subcellular localization of RNA-binding protein Arid5a. PNAS, 115: E1214-E1220 (2018)
当研究室が関わった著書 Nuclear Architecture and Dynamicsが刊行されました。
Miyamoto Y., Yoneda Y., Oka M. Protein Transport Between the Nucleus and Cytoplasm, Nuclear Architecture and Dynamics, Academic press, Chapter 17: 387-403 (2018)
Two isoforms of TALDO1 generated by alternative translational initiation show differential nucleocytoplasmic distribution to regulate the global metabolic network.
Moriyama T., Tanaka S., Nakayama Y., Fukumoto M., Tsujimura K., Yamada K., Bamba T., Yoneda Y., Fukusaki E., Oka M. Two isoforms of TALDO1 generated by alternative translational initiation show differential nucleocytoplasmic distribution to regulate the global metabolic network. Sci. Rep., 6: 34648 (2016)
Importin α: a key molecule in nuclear transport and non-transport functions
Miyamoto Y., Yamada K., Yoneda Y. Importin α: a key molecule in nuclear transport and non-transport functions. J. Biochem., 160: 69-75 (2016)
Data on dimer formation between importin α subtypes
Miyamoto Y., Oka M. Data on dimer formation between importin α subtypes. Data Brief, 7: 1248-1253 (2016)
Cell surface localization of importin α1/KPNA2 affects cancer cell proliferation by regulating FGF1 signalling
Yamada K., Miyamoto Y., Tsujii A., Moriyama Y., Ikuno Y., Shiromizu T., Serada S., Fujimoto M., Tomonaga T., Naka T., Yoneda Y. Oka M. Cell surface localization of importin α1/KPNA2 affects cancer cell proliferation by regulating FGF1 signalling. Sci. Rep., 6: 231410 (2016)
山田研究員が筆頭著者となった論文がScientific Reportsに掲載されました。
Chromatin-prebound Crm1 recruits Nup98-HoxA9 fusion to induce aberrant expression of Hox cluster genes
Oka M., Mura S., Yamada K., Sangel P., Hirata S., Maehara K., Kawakami K., Tachibana T., Ohkawa Y., Kimura H., Yoneda Y. Chromatin-prebound Crm1 recruits Nup98-HoxA9 fusion to induce aberrant expression of Hox cluster genes. eLIFE, 5: e09540 (2016)
Retinoblastoma Binding Protein 4-Regulated Classical Nuclear Transport Is Involved in Cellular Senescence
Tsujii A., Miyamoto Y., Moriyama T., Tsuchiya T., Obuse C., Mizuguchi K., Oka M., Yoneda Y. Retinoblastoma Binding Protein 4-Regulated Classical Nuclear Transport Is Involved in Cellular Senescence. J. Biol. Chem., 290: 29375–29388 (2015)
Functional characterization of importin α8 as a classical nuclear localization signal receptor.
Kimoto C., Moriyama T., Tsujii A., Igarashi Y., Obuse C., Miyamoto Y., Oka M. and Yoneda Y. Functional characterization of importin α8 as a classical nuclear localization signal receptor. Biochim. Biophys. Acta – Molecular Cell Research, 1853: 2676-2683 (2015)
Identification and characterization of a nuclear localization signal of TRIM28 that overlaps with the HP1 Box.
Moriyama T., Percival A. P., Yamaguchi D., Obuse C., Miyamoto Y., Oka M., Yoneda Y. Identification and characterization of a nuclear localization signal of TRIM28 that overlaps with the HP1 Box. Biochem. Biophys. Res. Commun., 462: 201–207 (2015)
The role of importin-βs in the maintenance and lineage commitment of mouse embryonic stem cells.
Sangel P., Oka M. and Yoneda Y. The role of importin-βs in the maintenance and lineage commitment of mouse embryonic stem cells. FEBS Open Bio, 4: 112-120 (2014)
Differential role for transcription factor Oct4 nucleocytoplasmic dynamics in somatic cell reprogramming and self-renewal of embryonic stem cells.
Oka M., Moriyama T., Asally M., Kawakami K. and Yoneda Y. Differential role for transcription factor Oct4 nucleocytoplasmic dynamics in somatic cell reprogramming and self-renewal of embryonic stem cells. J. Biol. Chem., 288: 15085-15097 (2013)
Importin alpha subtypes determine differential transcription factor localization in embryonic stem cells maintenance.
Yasuhara N., Yamagishi R., Arai Y., Mehmood R., Kimoto C., Fujita T., Touma K., Kaneko K., Kamikawa Y., Moriyama Y., Yanagida T., Kaneko H. and Yoneda Y. Importin alpha subtypes determine differential transcription factor localization in embryonic stem cells maintenance. Dev. Cell, 26: 123-135 (2013)
Quantitative regulation of nuclear pore complex components by O-GlcNAcylation.
Mizuguchi-Hata C., Ogawa Y., Oka M. and Yoneda Y. Quantitative regulation of nuclear pore complex components by O-GlcNAcylation. Biochim. Biophys. Acta -Molecular Cell Research, 1833: 2682-2689 (2013)
Cell density-dependent nuclear accumulation of ELK3 is involved in suppression of PAI-1 expression.
Tanaka S., Nakano K., Sekimoto T., Oka M. and Yoneda Y. Cell density-dependent nuclear accumulation of ELK3 is involved in suppression of PAI-1 expression.Cell Struct. Funct. 38: 145-154 (2013)
Differential role for transcription factor Oct4 nucleocytoplasmic dynamics in somatic cell reprogramming and self-renewal of embryonic stem cells.
Oka M., Moriyama T., Asally M., Kawakami K. and Yoneda Y. Differential role for transcription factor Oct4 nucleocytoplasmic dynamics in somatic cell reprogramming and self-renewal of embryonic stem cells. J. Biol. Chem., 288: 15085-15097 (2013)